一. The market demand for brain health products continues to expand

Over the past few years, there has been a huge increase in dietary supplements related to brain health. According to data from Allied Market Research, the global market size of brain health products was about 25 billion yuan in 2017 and is expected to reach 41.5 billion yuan in 2023, with a compound annual growth rate of 8.8%. In the US, for example, cognitive health in the brain health sector is the dominant market in 2021, according to research data: Overall sales of cognitive health ingredients in the mainstream US supplement market grew 59% to $366 million in 2021, compared to $230 million a year earlier.

二.Brain health effects and mechanism of phosphatidylserine PS

Phosphatidylserine PS is a mainstream cognitive health supplement ingredient in European and American markets, and has relatively high consumer awareness. Phosphatidylserine PS is a naturally occurring component in the cell membrane of organisms. It is one of the components of cell membrane and related to a series of membrane functions. Phosphatidylserine PS is especially abundant in the nervous system of the human body. There are about 30 grams in the human body, of which nearly half (13 grams) exist in the human brain, accounting for about 17% of the total phospholipid library of the brain, which plays an important role in regulating various functions of the brain.

Phosphatidylserine PS has been studied continuously since Jordi Folch first discovered it in bovine brains in 1942. So far, phosphatidylserine PS has been shown to improve cognitive decline as well as relieve stress and improve mood brain health, and has been adequately validated in the population. According to incomplete statistics, up to now, more than 3,000 people have participated in clinical studies on phosphatidylserine PS. The research objects include susceptible population (the elderly and children) and healthy individuals, and the efficacy and safety are fully supported by scientific research.

1. Improve cognitive decline

The primary function of phosphatidylserine PS is to improve cognitive decline, particularly associated with aging. Current research generally suggests that phosphatidylserine PS ameliorates cognitive decline through three mechanisms:

One is to maintain cell membrane function. Phosphatidylserine PS, as an important component of cell membrane, helps to increase cell mobility and has a positive effect on Na+/K+ stimulated ATPase (upregulation) and acetylcholinesterase (upregulation), which may lead to its influence on cognition.

The second is to help repair cell damage. Phosphatidylserine PS can increase the number of nerve cell spikes, help repair and renew damaged brain cells, restore the energy required for neurotransmitter transmission, slow down the aging of brain cells, help brain efficient operation, improve cognitive learning ability; The third is increased cholinergic, a chemical that brain cells use to communicate with each other. Reduced levels of acetylcholine can reduce communication between neurons, which can eventually lead to memory impairment, learning disabilities, and overall cognitive dysfunction. Phosphatidylserine PS can promote the synthesis and release of acetylcholine, and speed up the communication between brain cells, thus speeding up the speed of thinking.

2. Relieve stress and improve mood

A number of studies have shown that phosphatidylserine PS can significantly reduce excessive stress hormone levels in the body during work stress, relieve stress, relieve brain fatigue and improve mood. Cortisol is an emergency hormone produced by our body. The production of this hormone makes us feel pressure, anxiety, depression and so on. Adding PS can reduce the level of serum cortisol, thus improving mood and relieving stress. In addition, phosphatidylserine PS affects dopamine levels in the brain, helping to reduce the severity of depression.

PAS (phosphatidylserine and phosphatidic acid complex) effectively reduced serum cortisol response under social stress tests

三. Clinical research and application of phosphatidylserine PS+

As a powerful raw material for brain health, phosphatidylserine PS can be used as a dietary supplement in the form of a single active ingredient in product application. In the European and American markets, products using the single active ingredient of phosphatidylserine PS as a supplement have been very common and mature. In addition, phosphatidylserine PS, as a natural phospholipid component in the human body, has strong lipophilicity and is easy to be absorbed. When used together with other functional raw materials, it can play a more powerful functional effect. Meanwhile, the scheme of phosphatidylserine PS+ other functional raw materials can improve the market share and consumer awareness of the product.

1. Phosphatidylserine PS+DHA

DHA is an Omega-3 fatty acid that promotes the growth and protection of neurons and improves memory and thinking. PS is a kind of lipid molecule, which can strengthen the stability of neuronal membrane, promote the synthesis of neurotransmitters, improve the energy metabolism of brain cells, improve cognitive ability, relieve stress and improve mood. Studies have shown that DHA supplementation can promote the accumulation of phosphatidylserine PS in neurons, and this increase is specific to neurons. DHA and PS are capable of positively affecting the brain in different ways, and regular use together can produce synergies to further improve brain function and health. In clinical studies, subjects' cognitive status was effectively maintained or improved by taking 100mg of phosphatidylserine PS+DHA complex daily for 15 weeks. Another study of depressed patients who took PS (100mg) and omega-3 fatty acids (DHA 119mg and EPA 70mg) three times a day showed a significant decrease in Hamilton Depression Scale scores after 12 weeks, indicating that the phosphatidylserine PS+DHA complex, Can improve the mood of patients with depression.

2. Phosphatidylserine PS+ Ginkgo biloba leaf extract

Ginkgo biloba extract is a common natural medicine with a variety of health benefits, including promoting blood circulation and neuroprotection. It contains compounds that promote the growth of perivascular neurons and increase blood supply to the brain, thereby improving cognitive function and enhancing memory. Phosphatidylserine PS and ginkgo biloba extract are often used in combination to improve cognitive function and relieve anxiety.

Studies have shown that the bioavailability of ginkgo biloba extract is improved when it is used in combination with PS. A study published in Human Psychopharmacology in 2007 showed that 120mg of ginkgo biloba extract was not associated with a significant improvement in primary outcomes, while the memory performance of ginkgo biloba extract combined with PS was improved, including a significant increase in memory speed and memory quality; In addition, the results of emotional measurement showed that the combination of PS and Ginkgo biloba extract had a significant effect on calming emotions.

3. Phosphatidylserine PS+ curcumin

Curcumin is a yellow dye in turmeric, which has good antioxidant, anti-inflammatory and other health effects, can promote the growth and recovery of neurons, improve cognitive and memory functions. Some studies have found that phosphatidylserine PS and curcumin, when combined, can work synergically to improve the brain's ability to resist oxidative stress and neurodegeneration. In addition, curcumin can promote the absorption and utilization of phosphatidylserine PS, and accelerate its maintenance and repair of neurons. Phosphatidylserine PS can also increase the biological activity of curcumin and enhance its anti-inflammatory response. A 2016 study showed lower levels of pro-inflammatory cytokines (MCP-1, TNF-α, and IL-6) after ingestion of curcumin containing PS compared to curcumin or phosphatidylserine PS alone (p < 0.01), the levels of anti-inflammatory cytokines (TGF-β and IL-10) in oxLDL-activated macrophages were significantly increased (p < 0.01), indicating that the combination of curcumin and PS may play a more effective role in regulating the anti-inflammatory function of macrophages.

4. Introduction of PS advantages of L&P Phosphatidylserine

L&P Food Ingredient Co., Ltd. (hereinafter referred to as L&P) is a professional manufacturer of functional food ingredients, with nearly 40 years of production experience. L&P Food is the earliest manufacturer of phosphatidylserine PS in China. It officially established the production line of phosphatidylserine in 2015, and has become a top producer of phosphatidylserine productivity and quality in China.

L&P Phosphatidylserine PS is produced with proprietary intellectual property rights. It is made of natural non-transgenic soybean phospholipids or sunflower seeds phospholipids as raw materials and obtained through phospholipase biocatalyzation. The company has a complete range of manufacturing qualifications, including production permits, and certification systems: non-GMO (IP certification), quality (ISO 9001), food safety (ISO22000), religious (KOSHER, HALAL), Social responsibility (ISO 45001) and environmental system (ISO 14001); L&P supplies high-quality phosphatidylserine PS with perfect after-sales service and customized solutions.